Jay Guindon Posted August 23, 2010 Share Posted August 23, 2010 I’ve recently been doing some research into Conjugated Linoleic Acid, specifically the cis 9 trans 11 isomer, after hearing of it’s benefits as an anticarcinogen. Many studies done in vitro or on animals have shown C9 T11 to supress/prevent/reduce tumour growth, however all controlled studies in humans, while not specifically on cancer, seem to show negative or no effects of C9 T11. A few studies on humans show CLA to cause increased lipid peroxidation, which I would think would be a bad thing for health. See here http://www.ncbi.nlm.nih.gov/pubmed/10683436 and here http://www.ncbi.nlm.nih.gov/pubmed/10683436 and here http://www.ncbi.nlm.nih.gov/pubmed/18287358 This one showed CLA impaired endothelial function http://www.ncbi.nlm.nih.gov/pubmed/16339498 and these ones showed no benefit on immune function or blood lipids http://www.ncbi.nlm.nih.gov/pubmed/18287358 http://www.ncbi.nlm.nih.gov/pubmed/16600923 http://www.ncbi.nlm.nih.gov/pubmed/16549463http://www.ncbi.nlm.nih.gov/pubmed/15827560I can’t find the studies right now but it also seems to induce insulin resistance in human studies as well. Given all of this it seems to me that the poor effectiveness and negative effects of CLA in human studies does not correspond to animal or in vitro models and the majority of evidence on humans shows CLA is not beneficial and is probably detrimental. The increased lipid peroxidation is especially worrisome. Given the human evidence, is there something I’m missing? I had been including grassfed dairy in my diet because I was under the impression C9T11 was an amazing anti-cancer substance and dairy has a lot but now I feel that the evidence would lead me to take out anything I was eating solely to increase my CLA consumption. Can you shed some light on this? Am I missing something or am I on to something? Link to comment Share on other sites More sharing options...
Jay Guindon Posted August 24, 2010 Author Share Posted August 24, 2010 Sliz, Ido, trianglechoke? You guys are pretty thorough researchers, have you done any digging into CLA? Link to comment Share on other sites More sharing options...
Razz Posted August 24, 2010 Share Posted August 24, 2010 Interesting but way beyond my level. Ido is doing his US tour so he's probably not around. Link to comment Share on other sites More sharing options...
Jay Guindon Posted August 25, 2010 Author Share Posted August 25, 2010 I wasn't aware Ido was touring the US, that's cool. I feel like there must be something I'm missing because Robb and Mat both seem to still think CLA is one of the most potent anticarcinogens out there and I find it hard to believe they wouldn't have looked into the human studies when doing their research. Link to comment Share on other sites More sharing options...
Joshua Naterman Posted August 25, 2010 Share Posted August 25, 2010 I'm going to have to read those when I get the time before I can say anything about it! Link to comment Share on other sites More sharing options...
Jason Stein Posted August 27, 2010 Share Posted August 27, 2010 Jay,You are "onto something" with regards to eliminating milk, pastured or otherwise, from your diet.It has been shown to be very problematic for most humans, more so with post-industrial food-abundant societies.You may want to re-evaluate your food-choice strategies, as your original question sounds to me like a bit of Paleo 'nutrientism.'I'll be curious to hear Wolf's response, too. best with your training,jason Link to comment Share on other sites More sharing options...
Jay Guindon Posted August 28, 2010 Author Share Posted August 28, 2010 Generally I try to stay away from nutrientism but some specific nutrients are of particular interest such as curcumin, chlorophyll, and CLA. When I do look at a specific nutrient I do try and find studies that use the whole food product rather than an isolated nutrient which is why some of the studies are using butter or other high fat dairy products to see what happens. As I have seen, it is generally not favourable, unlike in a test tube or animals. Link to comment Share on other sites More sharing options...
Jason Stein Posted August 28, 2010 Share Posted August 28, 2010 Jay,What is the end-state you hope to arrive at when your question is answered? It sounds as if you are already aware of the many negative aspects of milk consumption; are you asking if you should supplement your pastured meat with additional isolated CLA intake?best,jason Link to comment Share on other sites More sharing options...
Neal Winkler Posted August 28, 2010 Share Posted August 28, 2010 No, I really haven't looked into CLA much. As I said in your other thread though, you really can't conclude anything by these abstracts because they don't tell you enough to evaluate the conclusions of studies. Link to comment Share on other sites More sharing options...
Jay Guindon Posted August 28, 2010 Author Share Posted August 28, 2010 Just wanted to know about CLA is all. I was under the impression it is good, while I know the abstracts don't give enough thorough information to make a real informed choice, unless they misreport their findings in the abstract, it still points in a certain direction for further investigation. From the abstracts I can decide whether this is something worth investing time and money into researching, or if there is enough in the abstract to dissuade me from researching further because I kind of have an idea. Anyways, at the end of the day, I will be removing even grassfed dairy from my diet. Link to comment Share on other sites More sharing options...
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