Interesting to note that Jefferson curls come from the world of powerlifting, where they have a rather more important function than they do here.
Think about standard form for a squat or Deadlift: you're supposed to keep a neutral spine position, perhaps erring on the side of hyper extension. While this is the safest way to build strength and avoid injury, what happens when you lose position? If you've only ever built strength isometrically in that one position, you're not going to be prepared to handle that kind of loading when you lose position.
So yes, done slowly and carefully, they will not only keep you healthy but will let you avoid injury as well.